The Jacquie Hirsch for A.L.L. Foundation


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Cause' when push        
        comes to shove
You taste what        
        you're made of.
You might bend,        
        till you break
Cause its all        
        you can take.
On your knees        
        you look up,
Decide you've        
        had enough.
You get mad,        
        you get strong,
Wipe your hands        
        shake it off,
Leukemia Research Project Updates
December 3, 2009
Roswell Park Board Room - 8th Floor
Present: Nancy Holiman, Dr. Eunice Wang, Torey Hirsch, Sharon Hirsch, TJ Hirsch
Update #1
- 24 patient samples of DNA hve been selected for the Leukemia Reseach Project. 1 sample is Jacquie's, which had been saved. The analysis, genes, chromosomes, micro RNA, statistics, correlation and gene sequence in both young and old patients (most of which succumbed to the disease) will be valuable information gained through this research.
- Details of the individuals, their ages, old vs. young, and an indepth look at their cancers will help determine where and what in their gene sequence went wrong. Were gene's 10x higher, 10x lower? etc. A collaborative effort with the University of Chicago will assist with analysis and correlation of the data.

Specifically: What is unique to each individual or unique to other patient samples; gene levels, protien levels and what occured between younger or older patients? How does this result in a cancer diagnosis or a specific cancer? Does this happen to A.L.L. patients? Does this happen to A.M.L. patients? The genes will be looked at and data summarized to see what went wrong.  In addition, why is leukemia so aggressive? Why does it resist chemotheraphy? Why, after transplantation, does it come back?


- First, will be the initial diagnosis of the patient samples then, why Jacquie's leukemia returned after bone marrow tranplantation.
- It is our understanding the gene cells can be broken down to show what makes it into leukemia. What makes it grow faster, what makes it grow slower, what makes it resistant to chemotheraphy?

"This is the patients cancer. How it happened and what went wrong is based on the genes. We are looking at new things with new technology. I want to look at the genes and have them tell me what went wrong" - Dr. Eunice Wang